Contact Us: The NCP Lab is located in the 3rd (Zen) Yard in the campus of Beijing Normal University , Beijing, China. Dr. Xiaohui Zhang ; Phone: (010) 5880-4978.
Exp. Tools: We use multiple approaches including electrophysiology (in vivo and slices), optogenetics, cellular imaging, and transgenic mouse models of brain diseases.
Research Direction
- Our research is focused on elucidating corticohippocampal circuitry mechanisms that underlie associative learning, spatial navigation and critical period plasticity of the brain.
Coincident binocular inputs mediate the critical period plasticity in V1
What correlated inputs from the two eyes are responsible for mediating the critical period plasticity in developing V1 remains unclear. Using <em>in vivo</em> whole-cell recording from the mouse V1, we demonstrate that the coincidence of binocular synaptic inputs from the two eyes is a hallmark of the critical period and serves as neural substrates for the induction of experience-dependent ocular dominance plasticity of the developing V1, through a homeostatic synaptic learning mechanism.